Search Results

Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors.

• Authors : Lu Sun¹; Kienzler, Jenny C.^1,2; Reynoso, Jeremy G.¹

Subjects: *BRAIN tumors; *IMMUNE checkpoint proteins; *T cells

• Source: Journal of Clinical Investigation. 9/1/2023, Vol. 133 Issue 17, p1-17. 17p.

Record details

Nutrient regulation of the islet epigenome controls adaptive insulin secretion.

• Authors : Wortham, Matthew¹; Fenfen Liu¹; Harrington, Austin R.¹

Subjects: *ADAPTIVE control systems; *INSULIN; *SECRETION

• Source: Journal of Clinical Investigation. 4/17/2023, Vol. 133 Issue 8, p1-15. 15p.

Record details

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.

• Authors : Abt, Evan R.¹; Rashid, Khalid¹; Le, Thuc M.¹

• Source: Journal of Clinical Investigation. 8/15/2022, Vol. 132 Issue 16, p1-15. 15p.

Record details

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair.

• Authors : Shen Li^1,2,3,4,5,6; Tomohiro Yokota^1,2,3,4,5,6; Ping Wang^1,2,3,4,5,6

Subjects: *MYOCARDIUM; *BIOSYNTHESIS; *HEART injuries

• Source: Journal of Clinical Investigation. 1/18/2022, Vol. 132 Issue 2, p1-21. 21p.

Record details

Foxo1 deletion promotes the growth of new lymphatic valves.

• Authors : Scallan, Joshua P.¹; Knauer, Luz A.¹; Huayan Hou¹

Subjects: *VALVES; *ENDOTHELIAL cells; *EDEMA

• Source: Journal of Clinical Investigation. 7/15/2021, Vol. 131 Issue 14, p1-13. 13p.

Record details

Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy.

• Authors : Yeon Joo Kim^1,2; Sheu, Katherine M.^1,3; Tsoi, Jennifer¹

Subjects: *MELANOMA; *CELL receptors; *INTERFERON gamma

• Source: Journal of Clinical Investigation. 6/15/2021, Vol. 131 Issue 12, p1-15. 15p.

Record details

Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia.

• Authors : Xinxia Zhu¹; Callahan, Michael F.²; Gruber, Kenneth A.^2,3,4

Subjects: *CACHEXIA; *ADIPOSE tissue diseases; *WASTING syndrome

• Source: Journal of Clinical Investigation. Sep2020, Vol. 130 Issue 9, p4921-4934. 14p. 1 Chart, 8 Graphs.

Record details

Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.

• Authors : Himburg, Heather A.¹; Roos, Martina^1,2; Tiancheng Fang^1,3

Subjects: *CHRONIC myeloid leukemia; *STEM cells; *PROTEIN-tyrosine kinases

• Source: Journal of Clinical Investigation. Jan2020, Vol. 130 Issue 1, p315-328. 14p.

Record details

Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.

• Authors : Meriwether, David^1,2; Sulaiman, Dawoud³; Volpe, Carmen⁴

Subjects: *INFLAMMATORY bowel diseases; *MEDICAL model; *CYCLOOXYGENASE 2

• Source: Journal of Clinical Investigation. Sep2019, Vol. 129 Issue 9, p3670-3685. 16p.

Record details

RASA1 regulates the function of lymphatic vessel valves in mice.

• Authors : Lapinski, Philip E.¹; Lubeck, Beth A.¹; Di Chen¹

Subjects: *ARTERIOVENOUS malformation; *LYMPHATIC diseases; *GENETIC mutation

• Source: Journal of Clinical Investigation. Jul2017, Vol. 127 Issue 7, p2569-2585. 17p. 2 Color Photographs, 9 Graphs.

Record details